Using a metaphor of a ball rolling down a landscape, these animations describe how a stem cell becomes static tissue cells such as skin, heart, blood vessel or brain cells. Each of the mode of action (MOA) animations show different ways this process can be reversed to create induced pluripotent stem cells and grow different types of cells from these converted skin tissue cells.
I was contracted through WAM Marketing Group to produces these animations for a presentation to nominate Gladstone Senior Investigator Shinya Yamanaka, MD, PhD. as a Nobel laureate. In 2012, Yamanaka was awarded the Nobel Prize in Physiology or Medicine for his discovery that adult somatic cells can be reprogrammed into pluripotent cells.
Induced Pluripotent Stem Cell Generation (iPS) MOA
iPS Direct Reprogramming MOA
iPS Direct Differentiation MOA
iPS Differentiation to Progenitor Cells MOA